Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training
Ashok Agarwal
(1)
,
Rakesh Sharma
(1)
,
Sajal Gupta
(1)
,
Renata Finelli
(1)
,
Neel Parekh
(1)
,
Manesh Kumar Panner Selvam
(1, 2)
,
Ralf Henkel
(1, 3, 4)
,
Damayanthi Durairajanayagam
(5)
,
Camila Pompeu
(6)
,
Sarah Madani
(7)
,
Andrea Belo
(8)
,
Neha Singh
(9)
,
Simryn Covarrubias
(10)
,
Sara Darbandi
(11)
,
Raha Sadeghi
(10)
,
Mahsa Darbandi
,
Paraskevi Vogiatzi
,
Florence Boitrelle
(12, 13)
,
Mara Simopoulou
(14)
,
Ramadan Saleh
(15)
,
Mohamed Arafa
(1, 16, 17)
,
Ahmad Majzoub
(1, 17)
,
Hussein Kandil
,
Armand Zini
(18)
,
Edmund Ko
(19)
,
Juan Alvarez
,
Marlon Martinez
(20)
,
Jonathan Ramsay
(21)
,
Sunil Jindal
,
Gian Maria Busetto
,
Hassan Sallam
(22)
,
Israel Maldonado
,
Christina Anagnostopoulou
,
Marco Alves
(23)
,
Pallav Sengupta
,
Kambiz Gilany
,
Donald Evenson
,
Sheena E.M. Lewis
(24)
,
Jaime Gosalvez
(25)
,
Rafael Ambar
,
Rupin Shah
1
Cleveland Clinic
2 Tulane University
3 Imperial College London
4 UWC - University of the Western Cape
5 UiTM - Universiti Teknologi MARA [Shah Alam]
6 Instituto Ideia Fèrtil
7 USTHB - Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene [Alger]
8 Huntington Centro de Medicina Reproditiva
9 NOVA IVF
10 USF - University of San Francisco
11 Fetal Health Research Center
12 BREED - Biologie de la Reproduction, Environnement, Epigénétique & Développement
13 CHI Poissy-Saint-Germain
14 NKUA - National and Kapodistrian University of Athens
15 Sohag University
16 Hamad medical corporation
17 Weill Cornell Medicine [Qatar]
18 McGill University = Université McGill [Montréal, Canada]
19 Loma Linda University
20 UNIVERSITY OF SANTO TOMAS MANILA PHL
21 Hammersmith Hospital NHS Imperial College Healthcare
22 Alexandria University [Alexandrie]
23 ICBAS - Instituto de Ciências Biomédicas de Abel Salazar
24 QUB - Queen's University [Belfast]
25 UAM - Universidad Autónoma de Madrid
2 Tulane University
3 Imperial College London
4 UWC - University of the Western Cape
5 UiTM - Universiti Teknologi MARA [Shah Alam]
6 Instituto Ideia Fèrtil
7 USTHB - Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene [Alger]
8 Huntington Centro de Medicina Reproditiva
9 NOVA IVF
10 USF - University of San Francisco
11 Fetal Health Research Center
12 BREED - Biologie de la Reproduction, Environnement, Epigénétique & Développement
13 CHI Poissy-Saint-Germain
14 NKUA - National and Kapodistrian University of Athens
15 Sohag University
16 Hamad medical corporation
17 Weill Cornell Medicine [Qatar]
18 McGill University = Université McGill [Montréal, Canada]
19 Loma Linda University
20 UNIVERSITY OF SANTO TOMAS MANILA PHL
21 Hammersmith Hospital NHS Imperial College Healthcare
22 Alexandria University [Alexandrie]
23 ICBAS - Instituto de Ciências Biomédicas de Abel Salazar
24 QUB - Queen's University [Belfast]
25 UAM - Universidad Autónoma de Madrid
Ashok Agarwal
- Fonction : Auteur
- PersonId : 770805
- ORCID : 0000-0003-0585-1026
- IdRef : 181655853
Ralf Henkel
- Fonction : Auteur
- PersonId : 807962
- ORCID : 0000-0003-1128-2982
Damayanthi Durairajanayagam
- Fonction : Auteur
- PersonId : 807963
- ORCID : 0000-0001-9049-0215
Mahsa Darbandi
- Fonction : Auteur
Paraskevi Vogiatzi
- Fonction : Auteur
- PersonId : 807964
- ORCID : 0000-0001-9971-1619
Florence Boitrelle
- Fonction : Auteur
- PersonId : 778478
- IdHAL : florenceboitrelle
- ORCID : 0000-0002-5322-0141
Mara Simopoulou
- Fonction : Auteur
- PersonId : 806701
- ORCID : 0000-0002-1000-9100
Mohamed Arafa
- Fonction : Auteur
- PersonId : 807966
- ORCID : 0000-0003-0107-8857
Hussein Kandil
- Fonction : Auteur
- PersonId : 807967
- ORCID : 0000-0002-5549-3274
Armand Zini
- Fonction : Auteur
- PersonId : 807968
- ORCID : 0000-0002-2194-5578
Juan Alvarez
- Fonction : Auteur
- PersonId : 756962
- ORCID : 0000-0002-4851-9579
Marlon Martinez
- Fonction : Auteur
- PersonId : 807970
- ORCID : 0000-0002-1191-8154
Jonathan Ramsay
- Fonction : Auteur
- PersonId : 807971
- ORCID : 0000-0002-2403-7698
Sunil Jindal
- Fonction : Auteur
- PersonId : 807972
- ORCID : 0000-0002-8088-8710
Gian Maria Busetto
- Fonction : Auteur
- PersonId : 807973
- ORCID : 0000-0002-7291-0316
Israel Maldonado
- Fonction : Auteur
Christina Anagnostopoulou
- Fonction : Auteur
- PersonId : 768576
- ORCID : 0000-0003-0999-6484
Pallav Sengupta
- Fonction : Auteur
- PersonId : 807974
- ORCID : 0000-0002-1928-5048
Kambiz Gilany
- Fonction : Auteur
Donald Evenson
- Fonction : Auteur
Jaime Gosalvez
- Fonction : Auteur
- PersonId : 807975
- ORCID : 0000-0003-3624-4261
- IdRef : 15424466X
Rafael Ambar
- Fonction : Auteur
Rupin Shah
- Fonction : Auteur
- PersonId : 807976
- ORCID : 0000-0002-7868-5949
Résumé
Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.
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