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Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training

Ashok Agarwal 1 Rakesh Sharma 1 Sajal Gupta 1 Renata Finelli 1 Neel Parekh 1 Manesh Kumar Panner Selvam 1, 2 Ralf Henkel 1, 3, 4 Damayanthi Durairajanayagam 5 Camila Pompeu 6 Sarah Madani 7 Andrea Belo 8 Neha Singh 9 Simryn Covarrubias 10 Sara Darbandi 11 Raha Sadeghi 10 Mahsa Darbandi Paraskevi Vogiatzi Florence Boitrelle 12, 13 Mara Simopoulou 14 Ramadan Saleh 15 Mohamed Arafa 1, 16, 17 Ahmad Majzoub 1, 17 Hussein Kandil Armand Zini 18 Edmund Ko 19 Juan Alvarez Marlon Martinez 20 Jonathan Ramsay 21 Sunil Jindal Gian Maria Busetto Hassan Sallam 22 Israel Maldonado Christina Anagnostopoulou Marco Alves 23 Pallav Sengupta Kambiz Gilany Donald Evenson Sheena E.M. Lewis 24 Jaime Gosalvez 25 Rafael Ambar Rupin Shah
Abstract : Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially sperm morphology assessment is very difficult to standardize and obtain reproducible results. This is mainly due to the highly subjective nature of their evaluation. ICSI is the choice of treatment when sperm morphology is severely abnormal (teratozoospermic). Hence, the standardization of laboratory protocols for sperm morphology evaluation represents a fundamental step to ensure reliable, accurate and consistent laboratory results that avoid misdiagnoses and inadequate treatment of the infertile patient. This article aims to promote standardized laboratory procedures for an accurate evaluation of sperm morphology, including the establishment of quality control and quality assurance policies. Additionally, the clinical importance of sperm morphology results in assisted reproductive outcomes is discussed, along with the clinical management of teratozoospermic patients.
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Submitted on : Tuesday, July 6, 2021 - 9:43:08 AM
Last modification on : Thursday, September 2, 2021 - 4:57:28 PM

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Ashok Agarwal, Rakesh Sharma, Sajal Gupta, Renata Finelli, Neel Parekh, et al.. Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training. The World Journal of Men's Health, 2021, 39, ⟨10.5534/wjmh.210054⟩. ⟨hal-03278904⟩

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