Skip to Main content Skip to Navigation
Journal articles

Strategies for Assessing Arbovirus Genetic Variability in Vectors and/or Mammals

Abstract : Animal arboviruses replicate in their invertebrate vectors and vertebrate hosts. They use several strategies to ensure replication/transmission. Their high mutation rates and propensity to generate recombinants and/or genome segment reassortments help them adapt to new hosts/emerge in new geographical areas. Studying arbovirus genetic variability has been used to identify indicators which predict their potential to adapt to new hosts and/or emergence and in particular quasi-species. Multiple studies conducted with insect-borne viruses laid the foundations for the "trade-off" hypothesis (alternation of host transmission cycle constrains arbovirus evolution). It was extrapolated to tick-borne viruses, where too few studies have been conducted, even though humans faced emergence of numerous tick-borne virus during the last decades. There is a paucity of information regarding genetic variability of these viruses. In addition, insects and ticks do not have similar lifecycles/lifestyles. Indeed, tick-borne viruses are longer associated with their vectors due to tick lifespan. The objectives of this review are: (i) to describe the state of the art for all strategies developed to study genetic variability of insect-borne viruses both in vitro and in vivo and potential applications to tick-borne viruses; and (ii) to highlight the specificities of arboviruses and vectors as a complex and diverse system.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03316125
Contributor : Camille Serva Connect in order to contact the contributor
Submitted on : Friday, August 6, 2021 - 11:57:01 AM
Last modification on : Wednesday, November 3, 2021 - 5:39:10 AM
Long-term archiving on: : Sunday, November 7, 2021 - 6:27:32 PM

File

2020_Migné_Pathogens.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Camille Migné, Sara Moutailler, Houssam Attoui. Strategies for Assessing Arbovirus Genetic Variability in Vectors and/or Mammals. Pathogens, MDPI, 2020, 9 (11), pp.1-18. ⟨10.3390/pathogens9110915⟩. ⟨hal-03316125⟩

Share

Metrics

Record views

46

Files downloads

108