Analytical Methods for the Detection and Quantification of ADCs in Biological Matrices - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Pharmaceuticals Année : 2020

Analytical Methods for the Detection and Quantification of ADCs in Biological Matrices

Résumé

Understanding pharmacokinetics and biodistribution of antibody-drug conjugates (ADCs) is a one of the critical steps enabling their successful development and optimization. Their complex structure combining large and small molecule characteristics brought out multiple bioanalytical methods to decipher the behavior and fate of both components in vivo. In this respect, these methods must provide insights into different key elements including half-life and blood stability of the construct, premature release of the drug, whole-body biodistribution, and amount of the drug accumulated within the targeted pathological tissues, all of them being directly related to efficacy and safety of the ADC. In this review, we will focus on the main strategies enabling to quantify and characterize ADCs in biological matrices and discuss their associated technical challenges and current limitations.
Fichier principal
Vignette du fichier
2020_Cahuzac_pharmaceuticals.pdf (1.42 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03320584 , version 1 (16-08-2021)

Licence

Paternité

Identifiants

Citer

Héloïse Cahuzac, Laurent Devel. Analytical Methods for the Detection and Quantification of ADCs in Biological Matrices. Pharmaceuticals, 2020, 13 (12), ⟨10.3390/ph13120462⟩. ⟨hal-03320584⟩
28 Consultations
112 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More