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Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions

Abstract : In this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications. These linkers react with cycloalkynes via subsequent [3+2] cycloaddition and retro Diels-Alder reactions, allowing simultaneous release of two dyes in biological media.
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https://hal.inrae.fr/hal-03321767
Contributor : Camille Serva <>
Submitted on : Wednesday, August 18, 2021 - 10:09:06 AM
Last modification on : Friday, August 20, 2021 - 3:26:57 AM

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Margaux Riomet, Karine Porte, Anne Wijkhuisen, Davide Audisio, Frédéric Taran. Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions. Chemical Communications, Royal Society of Chemistry, 2020, 56 (52), pp.7183-7186. ⟨10.1039/d0cc03067h⟩. ⟨hal-03321767⟩

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