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The C Type Lectins DC-SIGN and L-SIGN

Abstract : DC-SIGN and L-SIGN are C-type lectins that recognize carbohydrate structures present on viral glycoproteins and function as attachment factors for several enveloped viruses. DC-SIGN and L-SIGN enhance viral entry and facilitate infection of cells that express the cognate entry receptor (cis-infection). They are also able to capture viruses and transfer viral infections to other target cells (trans-infection). In this chapter, we will give an overview of protocols used to produce soluble viral glycoproteins at high levels and to study the molecular basis of viruses/DC-SIGN and L-SIGN binding and internalization. We will also describe techniques to investigate the molecular mechanisms by which DC-SIGN or L-SIGN spread viral infections.
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Contributor : Pierre-Yves Lozach <>
Submitted on : Wednesday, September 1, 2021 - 9:22:09 PM
Last modification on : Thursday, September 16, 2021 - 3:41:47 AM

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Pierre-Yves Lozach, Laura Burleigh, Isabelle Staropoli, Ali Amara. The C Type Lectins DC-SIGN and L-SIGN. Glycovirology protocols, 379, pp.51-68, 2007, Methods in Molecular Biology, 978-1-58829-590-3. ⟨10.1007/978-1-59745-393-6_4⟩. ⟨hal-03331577⟩



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