Skip to Main content Skip to Navigation
Journal articles

Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

Abstract : Tumor growth is accompanied with dramatic changes in the cellular glycome, such as the aberrant expression of complex branched N-glycans. However, the role of this protumoral N-glycan in immune evasion and whether its removal contributes to enhancement of immune recognition and to unleashing an antitumor immune response remain elusive. We demonstrated that branched N-glycans are used by colorectal cancer cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFN gamma. The removal of this "glycan-mask" exposed immunogenic mannose glycans that potentiated immune recognition by DC-SIGN-expressing immune cells, resulting in an effective antitumor immune response. We revealed a glycoimmune checkpoint in colorectal cancer, highlighting the therapeutic efficacy of its deglycosylation to potentiate immune recognition and, thus, improving cancer immunotherapy.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-03341273
Contributor : Roselyne Tâche <>
Submitted on : Friday, September 10, 2021 - 4:00:26 PM
Last modification on : Monday, September 13, 2021 - 2:04:22 PM

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Mariana Silva, Ângela Fernandes, Maria Oliveira, Carlos Resende, Alexandra Correia, et al.. Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression. Cancer Immunology Research, American Association for Cancer Research, 2020, 8 (11), pp.1407-1425. ⟨10.1158/2326-6066.CIR-20-0264⟩. ⟨hal-03341273⟩

Share

Metrics

Record views

12