Characterization and quantification of chlordecone elimination in ewes - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Environmental Toxicology and Pharmacology Year : 2021

Characterization and quantification of chlordecone elimination in ewes


To reduce the exposure of the French West Indies population to the organochlorine insecticide chlordecone (Kepone; CLD), the contamination of currently consumed foodstuffs must be reduced. Depuration of contaminated animals before slaughter could be a strategy to obtain safe animal products. The aim of this study was to characterize and quantify CLD elimination in contaminated ewes during depuration process. Experiments A and B consisted in a single intravenous (i.v.) administration of CLD (n = 5) and CLDOH (chlordecol; n = 3) followed by a 84-d and 3-d depuration period respectively with collection of blood, faeces and urine samples. After CLD administration, CLD and conjugated-CLDOH (CLDOH-C) were quantified in serum and urine and CLD and CLDOH were quantified in faeces. Based on calculations of faecal, urinary and body clearances of CLD and CLDOH-C, faeces appeared as the major route of CLD excretion with 86 % of the CLD administered dose eliminated in faeces, either as CLD (51 %) or as CLDOH (35 %).
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Dates and versions

hal-03515239 , version 1 (02-08-2023)


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Maïlie Saint-Hilaire, Aurore Fourcot, Alain Bousquet-Mélou, Guido Rychen, Jean-Pierre Thomé, et al.. Characterization and quantification of chlordecone elimination in ewes. Environmental Toxicology and Pharmacology, 2021, 87, pp.103698. ⟨10.1016/j.etap.2021.103698⟩. ⟨hal-03515239⟩
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