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A meta-analysis of ecotoxicological models used for plant protection product risk assessment before their placing on the market

Abstract : Before their placing on the market, the safety of plant protection products (PPP) towards both human and animal health, and the environment has to be assessed using experimental and modelling approaches. Models are crucial tools for PPP risk assessment and some even help to avoid animal testing. This review investigated the use of modelling approaches in the ecotoxicology section of PPP active substance assessment reports prepared by the authorities and opened to consultation from 2011 to 2021 in the European Union. Seven categories of models (Structure-Activity, ToxicoKinetic, ToxicoKinetic-ToxicoDynamic, Species Sensitivity Distribution, population, community, and mixture) were searched for into the reports of 317 active substances. At least one model category was found for 44 % of the investigated active substances. The most detected models were Species Sensitivity Distribution, Structure-Activity and ToxicoKinetic for 27, 21 and 15 % of the active substances, respectively. The use of modelling was of particular importance for conventional active substances such as sulfonylurea or carbamates contrary to microorganisms and plant derived substances. This review also highlighted a strong imbalance in model usage among the biological groups considered in the European Regulation (EC) No 1107/2009. For example, models were more often used for aquatic than for terrestrial organisms (e.g., birds, mammals). Finally, a gap between the set of models used in reports and those existing in the literature was observed highlighting the need for the implementation of more sophisticated models into PPP regulation.
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Submitted on : Tuesday, November 29, 2022 - 9:51:45 AM
Last modification on : Thursday, December 1, 2022 - 11:38:24 AM


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Floriane Larras, Rémy Beaudouin, Philippe Berny, Sandrine Charles, Arnaud Chaumot, et al.. A meta-analysis of ecotoxicological models used for plant protection product risk assessment before their placing on the market. Science of the Total Environment, 2022, 844, pp.157003. ⟨10.1016/j.scitotenv.2022.157003⟩. ⟨hal-03741237⟩



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