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Journal Articles Rheumatology International Year : 1990

Structural and biochemical abnormalities of articular cartilage in rheumatoid arthritis

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1
Nicole Darmon

Abstract

Compared with normal cartilage, the water content, extraction yields, and capacity of34SO4 incorporation, were found to be increased in articular cartilage from rheumatoid joints, which also synthesizes an increased proportion of low and middle density small size proteoglycans (PGs), enriched in dermatan sulfate. These small [35S]-PGs also possess longer glycosaminoglycan side chains and lack the ability to interact with hyaluronan. An altered pattern of PG synthesis of rheumatoid chondrocytes may contribute to cartilage damage in this condition.
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hal-03761562 , version 1 (26-08-2022)

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D. Mitrovic, Nicole Darmon. Structural and biochemical abnormalities of articular cartilage in rheumatoid arthritis. Rheumatology International, 1990, 10 (1), pp.31-37. ⟨10.1007/BF02274778⟩. ⟨hal-03761562⟩
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