Cyclic thrombocytopenia related to erythropoietin-dependent anti-platelet anti-GPIV/IIIb antibody in hemodialysis - Archive ouverte HAL Access content directly
Journal Articles Journal of Nephrology Year : 2022

Cyclic thrombocytopenia related to erythropoietin-dependent anti-platelet anti-GPIV/IIIb antibody in hemodialysis

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Abstract

We describe herein the case of a 65-year-old patient on chronic hemodialysis with a medical history of idiopathic thrombocytopenia who experienced numerous episodes of severe thrombocytopenia with no specific diagnosis. Further analysis of the evolution of the platelet count showed that cyclic thrombocytopenia occurred after each injection of recombinant erythropoietin (rHu-EPO). Exploration of the involved mechanisms revealed the presence of a rHu-EPO-dependent anti-GPIV/IIIb antibody associated with a significant increase in GPIV/IIIb expression on her platelets after the addition of rHu-EPO. EPO was discontinued and the patient was treated with roxadustat with favorable results on her hemoglobin and platelet counts.
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hal-03773864 , version 1 (09-09-2022)

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Attribution - CC BY 4.0

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Nans Florens, Jean-Claude Bordet, Catherine Giannoli, Emilie Le Toriellec, Fitsum Guebre-Egziabher. Cyclic thrombocytopenia related to erythropoietin-dependent anti-platelet anti-GPIV/IIIb antibody in hemodialysis. Journal of Nephrology, 2022, 35 (5), pp.1525-1529. ⟨10.1007/s40620-022-01348-3⟩. ⟨hal-03773864⟩
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