Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Veterinary Research Year : 2022

Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle

Abstract

Bovine respiratory disease (BRD) dramatically affects young calves, especially in fattening facilities, and is difficult to understand, anticipate and control due to the multiplicity of factors involved in the onset and impact of this disease. In this study we aimed to compare the impact of farming practices on BRD severity and on antimicrobial usage. We designed a stochastic individual-based mechanistic BRD model which incorporates not only the infectious process, but also clinical signs, detection methods and treatment protocols. We investigated twelve contrasted scenarios which reflect farming practices in various fattening systems, based on pen sizes, risk level, and individual treatment vs. collective treatment (metaphylaxis) before or during fattening. We calibrated model parameters from existing observation data or literature and compared scenario outputs regarding disease dynamics, severity and mortality. The comparison of the trade-off between cumulative BRD duration and number of antimicrobial doses highlighted the added value of risk reduction at pen formation even in small pens, and acknowledges the interest of collective treatments for high-risk pens, with a better efficacy of treatments triggered during fattening based on the number of detected cases.
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Origin : Publication funded by an institution
Licence : CC BY - Attribution
Comment : Main text
Format : Other
Licence : CC BY - Attribution
Comment : Additional information on the processes involved in the model (main article, section 1) and the whole content of the model (main article, section 2).
Format : Other
Licence : CC BY - Attribution
Comment : BRD model in EMULSION format. BRD model expressed within the modelling language used by the EMULSION simulation engine (based on YAML format). [NOTE: extension ".yaml.txt" instead of ".yaml" due to upload constraints]

Dates and versions

hal-03796118 , version 1 (04-10-2022)

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Sébastien Picault, Pauline Ezanno, Kristen Smith, David Amrine, Brad White, et al.. Modelling the effects of antimicrobial metaphylaxis and pen size on bovine respiratory disease in high and low risk fattening cattle. Veterinary Research, 2022, 53, pp.1-14. ⟨10.1186/s13567-022-01094-1⟩. ⟨hal-03796118⟩
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