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Journal Articles Neuroimage-Clinical Year : 2022

Intrasubject subcortical quantitative referencing to boost MRI sensitivity to Parkinson's disease

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Nicolas Carriere
  • Function : Author
Valerie Fraix
  • Function : Author
Elena Moro
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Stéphane Thobois
  • Function : Author
Elise Metereau
  • Function : Author
Graziella Mangone
  • Function : Author
Marie Vidailhet
  • Function : Author
Jean-Christophe Corvol
  • Function : Author
Stéphane Lehéricy
  • Function : Author
Nicolas Menjot de Champfleur
  • Function : Author
Christian Geny
  • Function : Author
Umberto Spampinato
  • Function : Author
Wassilios Meissner
  • Function : Author
Solène Frismand
  • Function : Author
Emmanuelle Schmitt
  • Function : Author
Anne Doé de Maindreville
  • Function : Author
Christophe Portefaix
  • Function : Author
Philippe Remy
  • Function : Author
Gilles Fénelon
  • Function : Author
Jean Luc Houeto
  • Function : Author
Olivier Colin
  • Function : Author
Olivier Rascol
  • Function : Author
Patrice Peran
  • Function : Author
Franck Durif
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Abstract

Several postmortem studies have shown iron accumulation in the substantia nigra of Parkinson's disease patients. Iron concentration can be estimated via MRI-R2∗ mapping. To assess the changes in R2∗ occurring in Parkinson's disease patients compared to controls, a multicentre transversal study was carried out on a large cohort of Parkinson's disease patients (n = 163) with matched controls (n = 82). In this study, 44 patients and 11 controls were removed due to motion artefacts, 21 patient and 6 controls to preserve matching. Thus, 98 patients and 65 age and sex-matched healthy subjects were selected with enough image quality. The study was conducted on patients with early to late stage Parkinson's disease. The images were acquired at 3Tesla in 12 clinical centres. R2∗ values were measured in subcortical regions of interest (substantia nigra, red nucleus, striatum, globus pallidus externus and globus pallidus internus) contralateral (dominant side) and ipsilateral (non dominant side) to the most clinically affected hemibody. As the observed inter-subject R2∗ variability was significantly higher than the disease effect, an original strategy (intrasubject subcortical quantitative referencing, ISQR) was developed using the measurement of R2∗ in the red nucleus as an intra-subject reference. R2∗ values significantly increased in Parkinson's disease patients when compared with controls; in the substantia nigra (SN) in the dominant side (D) and in the non dominant side (ND), respectively (PSN_D and PSN_ND < 0.0001). After stratification into four subgroups according to the disease duration, no significant R2∗ difference was found in all regions of interest when comparing Parkinson's disease subgroups. By applying our ISQR strategy, R2(ISQR)∗ values significantly increased in the substantia nigra (PSN_D and PSN_ND < 0.0001) when comparing all Parkinson's disease patients to controls. R2(ISQR)∗ values in the substantia nigra significantly increased with the disease duration (PSN_D = 0.01; PSN_ND = 0.03) as well as the severity of the disease (Hoehn & Yahr scale <2 and ≥ 2, PSN_D = 0.02). Additionally, correlations between R2(ISQR)∗ and clinical features, mainly related to the severity of the disease, were found. Our results support the use of ISQR to reduce variations not directly related to Parkinson's disease, supporting the concept that ISQR strategy is useful for the evaluation of Parkinson's disease.

Dates and versions

hal-03857470 , version 1 (17-11-2022)

Identifiers

Cite

Laila Khedher, Jean-Marie Bonny, Ana Marques, Elodie Durand, Bruno Pereira, et al.. Intrasubject subcortical quantitative referencing to boost MRI sensitivity to Parkinson's disease. Neuroimage-Clinical, 2022, 36, pp.103231. ⟨10.1016/j.nicl.2022.103231⟩. ⟨hal-03857470⟩
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