Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Pediatric Research Year : 2023

Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants

Pierre Kuhn
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  • PersonId : 1249149
Catherine Arnaud
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Antoine Burguet
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Gilles Cambonie
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Laurence Caeymaex
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Olivier Claris
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Catherine Gire
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Bernard Guillois
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Pierre Kuhn
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Bénédicte Lecomte
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Ayoub Mitha
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Hugues Patural
Jean-Charles Picaud
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Véronique Pierrat
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Jacques Sizun
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Pascal Boileau
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Marine Butin
Laurence Foix-L’hélias
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Christèle Gras-Le Guen
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Gilles Kayem
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Pierre Kuhn
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Mathilde Letouzey
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Elsa Lorthe
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Emeline Maisonneuve
Ayoub Mitha
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Jeanne Sibiude
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Héloïse Torchin

Abstract

Background To evaluate the association between exposure to early skin-to-skin contact (SSC) and incidence of late-onset sepsis (LOS) in extremely and very preterm infants. Methods Observational study using the national population-based EPIPAGE-2 cohort in 2011. A propensity score for SSC exposure was used to match infants with and without exposure to SSC before day 4 of life and binomial log regression used to estimate risk ratios and CIs in the matched cohort. The primary outcome was at least one episode of LOS during hospitalization. Secondary outcomes were the occurrence of any late-onset neonatal infection (LONI), LOS with Staphylococcus or Staphylococcus aureus, incidence of LOS and LONI per 1000 central venous catheter days. Results Among the 3422 included infants, 919 were exposed to early SSC. The risk ratio (RR) for LOS was 0.86 (95% CI, 0.67–1.10), for LONI was 1.00 (95% CI, 0.83–1.21), and for LOS with Coagulase-negative Staphylococcus or Staphylococcus aureus infection was 0.91 (95% CI, 0.68–1.21) and 0.77 (95% CI, 0.31–1.87). The incidence RR for LOS per-catheter day was 0.87 (95% CI, 0.64–1.18). Conclusion Early SSC exposure was not associated with LOS or LONI risk. Thus, their prevention should not be a barrier to a wider use of SSC.
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Dates and versions

hal-04076115 , version 1 (20-04-2023)

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Isabelle Le Ray, Pierre Kuhn, Mathilde Letouzey, Jean-Michel Roué, Ayoub Mitha, et al.. Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants. Pediatric Research, 2023, 93 (7), pp.2091-2100. ⟨10.1038/s41390-022-02383-3⟩. ⟨hal-04076115⟩
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