Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants
Isabelle Le Ray
(1)
,
Pierre Kuhn
(1)
,
Mathilde Letouzey
(2)
,
Jean-Michel Roué
(3)
,
Ayoub Mitha
(2)
,
Isabelle Glorieux
(4)
,
Laurence Foix-L’hélias
(2)
,
Laetitia Marchand-Martin
(2)
,
Pierre-Yves Ancel
(2)
,
Monique Kaminski
(2)
,
Véronique Pierrat
(2)
,
Catherine Arnaud
,
Antoine Burguet
,
Gilles Cambonie
,
Laurence Caeymaex
,
Olivier Claris
,
Catherine Gire
,
Bernard Guillois
,
Pierre Kuhn
,
Bénédicte Lecomte
,
Ayoub Mitha
,
Hugues Patural
,
Jean-Charles Picaud
,
Véronique Pierrat
,
Jean-Christophe Roze
(5)
,
Jacques Sizun
,
Pascal Boileau
,
Marine Butin
,
Laurence Foix-L’hélias
,
Christèle Gras-Le Guen
,
Gilles Kayem
,
Pierre Kuhn
,
Mathilde Letouzey
,
Elsa Lorthe
,
Emeline Maisonneuve
,
Ayoub Mitha
,
Jeanne Sibiude
,
Héloïse Torchin
Catherine Arnaud
- Function : Author
Antoine Burguet
- Function : Author
Gilles Cambonie
- Function : Author
Laurence Caeymaex
- Function : Author
Olivier Claris
- Function : Author
Catherine Gire
- Function : Author
Bernard Guillois
- Function : Author
Pierre Kuhn
- Function : Author
Bénédicte Lecomte
- Function : Author
Ayoub Mitha
- Function : Author
Hugues Patural
- Function : Author
- PersonId : 949048
- ORCID : 0000-0003-3984-6356
- IdRef : 142302279
Jean-Charles Picaud
- Function : Author
Véronique Pierrat
- Function : Author
Jacques Sizun
- Function : Author
Pascal Boileau
- Function : Author
Marine Butin
- Function : Author
- PersonId : 1079314
- IdHAL : marinebutinchu-lyonfr
Laurence Foix-L’hélias
- Function : Author
Christèle Gras-Le Guen
- Function : Author
Gilles Kayem
- Function : Author
Pierre Kuhn
- Function : Author
Mathilde Letouzey
- Function : Author
Elsa Lorthe
- Function : Author
Emeline Maisonneuve
- Function : Author
- PersonId : 1225055
- ORCID : 0000-0001-5765-4468
Ayoub Mitha
- Function : Author
Jeanne Sibiude
- Function : Author
Héloïse Torchin
- Function : Author
- PersonId : 805660
- IdHAL : heloise-torchin
- ORCID : 0000-0003-4699-5384
Abstract
Background
To evaluate the association between exposure to early skin-to-skin contact (SSC) and incidence of late-onset sepsis (LOS) in extremely and very preterm infants.
Methods
Observational study using the national population-based EPIPAGE-2 cohort in 2011. A propensity score for SSC exposure was used to match infants with and without exposure to SSC before day 4 of life and binomial log regression used to estimate risk ratios and CIs in the matched cohort. The primary outcome was at least one episode of LOS during hospitalization. Secondary outcomes were the occurrence of any late-onset neonatal infection (LONI), LOS with Staphylococcus or Staphylococcus aureus, incidence of LOS and LONI per 1000 central venous catheter days.
Results
Among the 3422 included infants, 919 were exposed to early SSC. The risk ratio (RR) for LOS was 0.86 (95% CI, 0.67–1.10), for LONI was 1.00 (95% CI, 0.83–1.21), and for LOS with Coagulase-negative Staphylococcus or Staphylococcus aureus infection was 0.91 (95% CI, 0.68–1.21) and 0.77 (95% CI, 0.31–1.87). The incidence RR for LOS per-catheter day was 0.87 (95% CI, 0.64–1.18).
Conclusion
Early SSC exposure was not associated with LOS or LONI risk. Thus, their prevention should not be a barrier to a wider use of SSC.