Activation of proto-oncogenes by disruption of chromosome neighborhoods - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Science Year : 2016

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Abstract

The spread of bad neighborhoods Our genomes have complex three-dimensional (3D) arrangements that partition and regulate gene expression. Cancer cells frequently have their genomes grossly rearranged, disturbing this intricate 3D organization. Hnisz et al. show that the disruption of these 3D neighborhoods can bring oncogenes under the control of regulatory elements normally kept separate from them (see the Perspective by Wala and Beroukim). These novel juxtapositions can result in the inappropriate activation of oncogenes. Science , this issue p. 1454 ; see also p. 1398

Dates and versions

hal-04172243 , version 1 (27-07-2023)

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Denes Hnisz, Abraham Weintraub, Daniel Day, Anne-Laure Valton, Rasmus Bak, et al.. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science, 2016, 351 (6280), pp.1454-1458. ⟨10.1126/science.aad9024⟩. ⟨hal-04172243⟩
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