MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles iScience Year : 2023

MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae

Stefan Jacob
  • Function : Author
Ying Zheng
  • Function : Author
Parviz Ghezellou
  • Function : Author
Martin Gand
  • Function : Author
Wendell Albuquerque
  • Function : Author
Jafargholi Imani
  • Function : Author
Bernhard Spengler
  • Function : Author
Eckhard Thines
  • Function : Author

Abstract

Macrophage migration inhibitory factor (MIF) is a pleiotropic protein with chemotactic, pro-inflammatory, and growth-promoting activities first discovered in mammals. In parasites, MIF homologs are involved in immune evasion and pathogenesis. Here, we present the first comprehensive analysis of an MIF protein from the devastating plant pathogen Magnaporthe oryzae (Mo). The fungal genome encodes a single MIF protein (MoMIF1) that, unlike the human homolog, harbors multiple low-complexity regions (LCRs) and is unique to Ascomycota. Following infection, MoMIF1 is expressed in the biotrophic phase of the fungus, and is strongly down-regulated during subsequent necrotrophic growth in leaves and roots. We show that MoMIF1 is secreted during plant infection, affects the production of the mycotoxin tenuazonic acid and inhibits plant cell death. Our results suggest that MoMIF1 is a novel key regulator of fungal virulence that maintains the balance between biotrophy and necrotrophy during the different phases of fungal infection.
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Dates and versions

hal-04297939 , version 1 (21-11-2023)

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Stefan Jacob, Ying Zheng, Parviz Ghezellou, Martin Gand, Wendell Albuquerque, et al.. MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae. iScience, 2023, 26, ⟨10.1016/j.isci.2023.107565⟩. ⟨hal-04297939⟩
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