The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Journal of Leukocyte Biology Year : 2011

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

Ronan Kapetanovic
David Hume
  • Function : Author

Abstract

ABSTRACT The biology of cells of the mononuclear phagocyte system has been studied extensively in the mouse. Studies of the pig as an experimental model have commonly been consigned to specialist animal science journals. In this review, we consider some of the many ways in which the innate immune systems of humans differ from those of mice, the ways that pigs may address the shortcomings of mice as models for the study of macrophage differentiation and activation in vitro, and the biology of sepsis and other pathologies in the living animal. With the completion of the genome sequence and the characterization of many key regulators and markers, the pig has emerged as a tractable model of human innate immunity and disease that should address the limited, predictive value of rodents in preclinical studies.
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hal-04405858 , version 1 (19-01-2024)

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Lynsey Fairbairn, Ronan Kapetanovic, David Sester, David Hume. The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. Journal of Leukocyte Biology, 2011, 89 (6), pp.855-871. ⟨10.1189/jlb.1110607⟩. ⟨hal-04405858⟩

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