Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Microbes and Infection Year : 2010

Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

Abstract

Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted in intensive-care units, causing septicaemia or pneumonia. In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed. Nod2-/- mice showed a reduced lung inflammation in comparison to wild-type animals, with lower presence of cytokines in broncho-alveolar lavage fluids and reduced recruitment of neutrophils. Furthermore, histological analysis of the lungs revealed less severe lesions in Nod2-/- mice at day 2 and day 7 post-infection. In conclusion, we demonstrated that NOD2 is not a crucial receptor to fight S. aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery.

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hal-04405901 , version 1 (19-01-2024)

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Ronan Kapetanovic, Gregory Jouvion, Catherine Fitting, Marianna Parlato, Charlène Blanchet, et al.. Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia. Microbes and Infection, 2010, 12 (10), pp.759-767. ⟨10.1016/j.micinf.2010.05.003⟩. ⟨hal-04405901⟩

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