Prevalence of pretreatment HIV resistance to integrase inhibitors in West African and Southeast Asian countries - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Journal of Antimicrobial Chemotherapy Year : 2024

Prevalence of pretreatment HIV resistance to integrase inhibitors in West African and Southeast Asian countries

Almoustapha Maiga
  • Function : Author
Marie-Laure Chaix
Truong Xuan Lien
  • Function : Author
Martine Peeters
  • Function : Author
Jean-Christophe Plantier
  • Function : Author
Richard Njouom
  • Function : Author
Edouard Tuaillon
  • Function : Author
Thomas D’aquin Toni
  • Function : Author
Armel Poda
  • Function : Author
Jacques Zougrana
  • Function : Author
Saidou Ouedraogo
  • Function : Author
Macaire Ouedraogo
  • Function : Author
Eugene Messou
  • Function : Author
Jean Jacques Dechi
  • Function : Author
Jean François Nguessan
  • Function : Author
Oumar Dolo
  • Function : Author
Zoumana Diarra
  • Function : Author
Mamadou Cisse
  • Function : Author
Akouda Patassi
  • Function : Author
Mounérou Salou
  • Function : Author
Komla Ali-Edjé
  • Function : Author
Chureeratana Bowonwatanuwong
  • Function : Author
Suchart Thongpaen
  • Function : Author
Virat Klinbuayaem
  • Function : Author
Laddawan Laomanit
  • Function : Author
Que Anh Luong
  • Function : Author
Ton Tran
  • Function : Author

Abstract

Objectives: Integrase strand transfer inhibitors (INSTIs) have been recently recommended as the preferred first-line option for antiretroviral treatment initiators in low- and middle-income countries (LMICs) in response to the growing circulation of resistant HIV to non-nucleoside reverse transcriptase inhibitors (NNRTIs). In this study, we estimated the frequency of pretreatment drug resistance (PDR) to INSTIs in West Africa and Southeast Asia. Materials and methods: Using samples collected from 2015 to 2016, and previously used to assessed PI, NRTI and NNRTI resistance, we generated HIV integrase sequences and identified relevant INSTI PDR mutations using the Stanford and ANRS algorithms. Results: We generated 353 integrase sequences. INSTI PDR frequency was low, 1.1% (4/353) overall, ranging from 0% to 6.3% according to country. However, frequency of PDR to any drug class was very high, 17.9% (95% CI: 13.9%–22.3%), and mostly associated with a high level of NNRTI PDR, 9.7%, and a moderate level of NRTI PDR, 5.3%. Conclusions: Our results support the recent introduction of INSTIs in LMICs to improve treatment outcome in these settings, but also stress the need for effective actions to prevent uncontrolled emergence of drug resistance to this drug class.
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Dates and versions

hal-04533843 , version 1 (05-04-2024)

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Avelin Aghokeng, Nicole Ngo-Giang-Huong, Thu Huynh, Anoumou Dagnra, Thomas D’aquin Toni, et al.. Prevalence of pretreatment HIV resistance to integrase inhibitors in West African and Southeast Asian countries. Journal of Antimicrobial Chemotherapy, 2024, online first (dkae087), ⟨10.1093/jac/dkae087⟩. ⟨hal-04533843⟩
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