Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Allergy Year : 2024

Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study

1 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
2 EUR - European University of Rome
3 Ospedale Policlinico Casilino - Policlinico Casilino
4 DET - Department of Electronics and Telecommunications [Florence]
5 Ankara Yildirim Beyazit University [Turkey]
6 University of Athens Medical School [Athens]
7 University of Messina
8 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
9 University of Évora [Portugal]
10 Ege University [Izmir]
11 APPA - Association pour la Prévention de la Pollution Atmosphérique
12 Centro Hospitalar do Porto
13 UR REVERSAAL - Réduire, valoriser, réutiliser les ressources des eaux résiduaires
14 Universidade do Porto = University of Porto
15 UCBM - Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome
16 TIMONE - Hôpital de la Timone [CHU - APHM]
17 Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe
18 HU Berlin - Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
19 University of Kirikkale
20 University of Tirana
21 Istanbul Arel University
22 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
23 ARPA Piemonte Regional Agency for Environmental Protection
24 Ankara Üniversitesi
25 Athens Naval Hospital
26 Istanbul University
27 University of Oviedo
28 Réseau National de Surveillance Aérobiologique, Brussieu
29 Istanbul Kemerburgaz University [Istanbul]
30 Dpt of Cardiology [Berlin]
S. Tripodi
  • Function : Author
  • PersonId : 1079241
A. Bourgoin
  • Function : Author
B. Bregu
  • Function : Author
O. Goksel
B. Lame
  • Function : Author
G. Pajno
  • Function : Author
A. Pereira
N. Pinar
  • Function : Author
F. Psarros
  • Function : Author
C. Sackesen
J. Suarez
  • Function : Author
U. Uguz
  • Function : Author
P. Matricardi

Abstract

Background Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central and Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern European countries with a standardized approach. Objective To describe sensitization profiles and clinical phenotypes of pollen allergic patients in nine Southern European cities with a uniform methodological approach. Methods Within the @IT.2020 multicenter observational study, pediatric and adult patients suffering from SAR were recruited in nine urban study centers located in seven countries. Clinical questionnaires, skin prick tests (SPT) and specific IgE (sIgE) tests with a customized multiplex assay (Euroimmun Labordiagnostika, Lübeck, Germany) were performed. Results Three hundred forty‐eight children (mean age 13.1 years, SD: 2.4 years) and 467 adults (mean age 35.7 years SD: 10.0 years) with a predominantly moderate to severe, persistent phenotype of SAR were recruited. Grass pollen major allergenic molecules (Phl p 1 and/or Phl p 5) ranged among the top three sensitizers in all study centers. Sensitization profiles were very heterogeneous, considering that patients in Rome were highly poly‐sensitized (sIgE to 3.8 major allergenic molecules per patient), while mono‐sensitization was prominent and heterogeneous in other cities, such as Marseille (sIgE to Cup a 1: n = 55/80, 68.8%) and Messina (sIgE to Par j 2: n = 47/82, 57.3%). Co‐sensitization to perennial allergens, as well as allergic comorbidities also broadly varied between study centers. Conclusions In Southern European countries, pollen allergy is heterogeneous in terms of sensitization profiles and clinical manifestations. Despite the complexity, a unique molecular, multiplex, and customized in‐vitro IgE test detected relevant sensitization in all study centers. Nevertheless, this geographical diversity in pollen allergic patients imposes localized clinical guidelines and study protocols for clinical trials of SAR in this climatically complex region.
Fichier principal
Vignette du fichier
Allergy - 2024 - Dramburg.pdf (15.23 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives

Dates and versions

hal-04574624 , version 1 (14-05-2024)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

S. Dramburg, U. Grittner, E. Potapova, A. Travaglini, S. Tripodi, et al.. Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study. Allergy, 2024, 79 (4), pp.908-923. ⟨10.1111/all.16029⟩. ⟨hal-04574624⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More