Pig health is a major concern for society in terms of animal welfare, reducing antibiotic use and limiting antibiotic resistance, as raising pigs without antibiotics can be challenging due to high disease incidences and compromised performance. As the genetic improvement of animal health could supplement traditional disease control in livestock, Tthe aim of this study was to simulate a breeding scheme to investigate whether it is possible to select for a health trait recorded only for crossbred animals. The simulated scenarios differed in the percentage of 1000 crossbred animals with known pedigrees that were genotyped and phenotyped (i.e. 10 %, 25 %, 50 %, 75 % and 100 %). Purebred animals were selected based on either (i) Genomic estimated breeding values (GEBV) for crossbred performance when considering trait 2 (health trait) only or (ii) an index that equalled the sum of the GEBV for crossbred performance for trait 1 (average daily gain) and trait 2. As expected, the cumulative genetic gain and accuracy of GEBV increased as the percentage of crossbred animals with phenotypes and genotypes included in genetic evaluations increased. When evaluating trait 2 only, the maximum genetic gain achieved in generation 10 ranged from 1.17 to-2.89. When trait 2 was evaluated with trait 1, the maximum genetic gain attained in generation 10 was 0.50, 0.85, 1.28, 1.54 and 1.75, while the cumulative accuracy in generation 10 was 0.29, 0.36, 0.42, 0.44 and 0.40, for scenarios with 10 %, 25 %, 50 %, 75 % and 100% of crossbred animals, respectively considered. The next step will be to extend thisese studyies to a three-way crossbreeding scheme that will mimic a real-world swine-breeding program. If a trait, such as a health trait, is difficult or impossible to record for purebreds, crossbred phenotypes from commercial farms can be used to improve this trait in purebreds.