Using bibliometric methods, this paper is aimed at providing an overview of Regional Science publications that address environmental issues. The analysis covers a corpus of 1145 articles that refer to the environment in their title, abstract or keywords and published in 18 journals between 1999 and 2020. Although these publications account for only 6 percent of the articles published in these journals over that period, their number gradually increased. To gain a clearer picture of the environmental issues addressed, we characterise them according to whether an integrative or topical approach is adopted and by their spatial dimensions. This analytical framework is first applied by searching for specific terms in their title, keywords and abstract. The results show that both approaches are equally effective; further, these articles address intraregional or interregional environmental issues more than global environmental issues. Second, we conduct a keyword co-occurrence analysis revealing four coherent thematic article groups treating environmental issues from the perspectives of amenities and migration, governance and policy, innovation and clusters, and land use and urban sprawl. More detailed analyses of each group allowed us to refine our understanding of how environmental issues were addressed. Finally, a cross-cutting view of the four thematic groups suggests that Regional Science approaches environmental issues through spatial disparities and inequalities, spatial interactions and interdependencies, and the spatial dimension of public action. The research perspectives in each of these areas are highlighted.