Genome sequence of the model medicinal mushroom Ganoderma lucidum - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Nature Communications Year : 2012

Genome sequence of the model medicinal mushroom Ganoderma lucidum

Jiang Xu
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  • PersonId : 776757
  • IdRef : 196826055
Chang Liu
Ying Li
Jun Qian
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  • PersonId : 758964
  • IdRef : 188948538
Jin Zhang
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  • PersonId : 758884
  • IdRef : 150560842
Zhen Wang
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  • PersonId : 766969
  • IdRef : 192906518
Chao Sun


Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. Here we report its 43.3-Mb genome, encoding 16,113 predicted genes, obtained using next-generation sequencing and optical mapping approaches. The sequence analysis reveals an impressive array of genes encoding cytochrome P450s (CYPs), transporters and regulatory proteins that cooperate in secondary metabolism. The genome also encodes one of the richest sets of wood degradation enzymes among all of the sequenced basidiomycetes. In all, 24 physical CYP gene clusters are identified. Moreover, 78 CYP genes are coexpressed with lanosterol synthase, and 16 of these show high similarity to fungal CYPs that specifically hydroxylate testosterone, suggesting their possible roles in triterpenoid biosynthesis. The elucidation of the G. lucidum genome makes this organism a potential model system for the study of secondary metabolic pathways and their regulation in medicinal fungi.
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hal-01268167 , version 1 (29-05-2020)



Shilin Chen, Jiang Xu, Chang Liu, Yingjie Zhu, David R Nelson, et al.. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Communications, 2012, 3, pp.1-9. ⟨10.1038/ncomms1923⟩. ⟨hal-01268167⟩
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