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Journal Articles Science of the Total Environment Year : 2017

Global metabolome changes induced by cyanobacterial blooms in three representative fish species

Abstract

Cyanobacterial blooms induce important ecological constraints for aquatic organisms and strongly impact the functioning of aquatic ecosystems. In the past decades, the effects of the cyanobacterial secondary metabolites, so called cyanotoxins, have been extensively studied in fish. However, many of these studies have used targeted approaches on specific molecules, which are thought to react to the presence of these specific cyanobacterial compounds. Since a few years, untargeted metabolomic approaches provide a unique opportunity to evaluate the global response of hundreds of metabolites at a glance. In this way, our study provides the first utilization of metabolomic analyses in order to identify the response of fish exposed to bloom-forming cyanobacteria. Three relevant fish species of peri-urban lakes of the European temperate regions were exposed for 96 h either to a microcystin (MC)-producing or to a non-MC-producing strain of Microcystis aeruginosa and metabolome changes were characterized in the liver of fish. The results suggest that a short-term exposure to those cyanobacterial biomasses induces metabolome changes without any response specificity linked to the fish species considered. Candidate metabolites are involved in energy metabolism and antioxidative response, which could potentially traduce a stress response of fish submitted to cyanobacteria. These results are in agreement with the already known information and could additionally bring new insights about the molecular interactions between cyanobacteria and fish.
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hal-01602675 , version 1 (02-10-2017)

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Benoît Sotton, Alain Paris, Severine Le Manach, Alain Blond, Gérard Lacroix, et al.. Global metabolome changes induced by cyanobacterial blooms in three representative fish species. Science of the Total Environment, 2017, 590, pp.333-342. ⟨10.1016/j.scitotenv.2017.03.016⟩. ⟨hal-01602675⟩
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