Growing insights into the safety of bacteriocins: the case of enterocin S37 - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Research in Microbiology Year : 2011

Growing insights into the safety of bacteriocins: the case of enterocin S37

Abstract

Very few studies have been reported on the cytotoxicity and impact of bacteriocins, and especially enterocins, upon eukaryotic cells. In order to gain more information on the safety of bacteriocins, we focused this study on enterocin S37, a bacteriocin produced by Enterococcus faecalis S37. We observed dose-dependent cytotoxicity toward undifferentiated Caco-2/TC7 cells. Moreover, no significant effect on differentiated monolayer Caco-2/TC7 and no apoptotic features were observed when cells were treated with 10 μg/ml of enterocin S37. The results obtained indicate possible safe use of enterocin S37 in the gastrointestinal tract of animals to prevent pathogen invasion and/or infection.

Dates and versions

hal-01938264 , version 1 (28-11-2018)

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Yanath Belguesmia, Amar Madi, Daniel Sperandio, Annabelle Mérieau, Marc Feuilloley, et al.. Growing insights into the safety of bacteriocins: the case of enterocin S37. Research in Microbiology, 2011, 162 (2), pp.159 - 163. ⟨10.1016/j.resmic.2010.09.019⟩. ⟨hal-01938264⟩
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