Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Candida Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Frontiers in Microbiology Year : 2018

Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Candida Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort

Abstract

BACKGROUND:The link between Candida phenotypical characteristics and invasive candidiasis (IC) prognosis is still partially unknown. METHODS:Candida strains isolated during the AmarCAND2 study were centrally analyzed for species identification, antifungal susceptibility, biofilm formation, and expression of surface and glycoconjugate mannosides. Correlation between these phenotypical features and patient outcome was sought using a multivariable Cox survival model. RESULTS:Candida albicans was predominant (65.4%, n = 285), with a mortality rate significantly lower than that in patients with non-albicans strains [HR 0.67 (0.46-1.00), p = 0.048]. The rate of fluconazole-resistant strains was low (C. albicans and Candida glabrata 3.5 and 6.2%, respectively) as well as caspofungin-resistant ones (1 and 3.1%, respectively). Early biofilm formation was less frequent among C. albicans (45.4%) than among non-albicans (81.2%). While the strains of C. albicans showed variable levels of surface mannosides expression, strains isolated from candidemia exhibited a high expression of beta-man, which was correlated with an increased mortality (p = 0.02). CONCLUSION:Candida albicans IC were associated with lower mortality, and with strains that exhibited less frequently early biofilm formation than non-albicans strains. A high expression of beta-man was associated with increased IC mortality. Further studies are warranted to confirm this data and to evaluate other virulence factors in yeasts.
Fichier principal
Vignette du fichier
pdf (3.73 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-01978477 , version 1 (18-07-2019)

Licence

Attribution

Identifiers

Cite

Jean-Pierre Gangneux, Muriel Cornet, Sébastien Bailly, Chantal Fradin, Celine Feger, et al.. Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Candida Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort. Frontiers in Microbiology, 2018, 9, pp.2907. ⟨10.3389/fmicb.2018.02907⟩. ⟨hal-01978477⟩
164 View
41 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More