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Journal Articles European Respiratory Journal Year : 2015

Prognostic value of right ventricular ejection fraction in pulmonary arterial hypertension

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1
P. Y. Courand
G. Pina Jomir
  • Function : Author
C. Scheiber
  • Function : Author
J. C. Glerant
  • Function : Author
B. Mastroianni
  • Function : Author
B. Gentil
  • Function : Author
A. S. Blanchet-Legens
  • Function : Author
G. Derumeaux
  • Function : Author
M. Humbert
  • Function : Author
Vincent Cottin
  • Function : Author
  • PersonId : 1071366

Abstract

Right ventricle ejection fraction (RVEF) evaluated with magnetic resonance imaging is a strong determinant of patient outcomes in pulmonary arterial hypertension. We evaluated the prognostic value of RVEF assessed with conventional planar equilibrium radionuclide angiography at baseline and change 3-6 months after initiating pulmonary arterial hypertension-specific therapy. In a prospective cohort of newly diagnosed patients with idiopathic, heritable or anorexigen-associated pulmonary arterial hypertension, RVEF was measured at baseline (n=100) and 3-6 months after initiation of therapy (n=78). After a median follow-up of 4.1 years, 41 deaths occurred, including 35 from cardiovascular causes. Patients with a (median) baseline RVEF \\textgreater25% had better survival than those with a RVEF \\textless25% using Kaplan-Meier analysis (p=0.010). RVEF at baseline was an independent predictor of all-cause and cardiovascular mortality in adjusted Cox regression model (p=0.002 and p=0.007, respectively; HR 0.93 for both). Patients with stable or increased RVEF at 3-6 months had a trend for improved all-cause survival (HR 2.43, p=0.086) and had less cardiovascular mortality (HR 3.25, p=0.034) than those in whom RVEF decreased despite therapy. RVEF assessed with conventional planar equilibrium radionuclide angiography at baseline and change in RVEF 3-6 months after therapy initiation independently predict outcomes in patients with pulmonary arterial hypertension.

Dates and versions

hal-02192923 , version 1 (24-07-2019)

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P. Y. Courand, G. Pina Jomir, Chahéra Khouatra, C. Scheiber, Ségolène Turquier, et al.. Prognostic value of right ventricular ejection fraction in pulmonary arterial hypertension. European Respiratory Journal, 2015, 45 (1), pp.139-49. ⟨10.1183/09031936.00158014⟩. ⟨hal-02192923⟩
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