Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Time course of fractional gluconeogenesis after meat ingestion in healthy adults: a D 2 O study

Abstract : In the postprandial state, glucose homeostasis is challenged by macronutrient intake, including proteins that trigger insulin secretion and provide glucose precursors. However, little is known about the postprandial response of gluconeogenesis to a protein meal. We aimed to quantify the evolution of fractional gluconeogenesis after a meat meal. Thirteen healthy subjects received oral doses of D2O. After fasting overnight, they ingested a steak (120 g). Glycemia, insulinemia, and 2H enrichments in glucose and plasma water were measured for 8 h after the meal. Fractional gluconeogenesis was assessed using the average method. Glucose was stable for 5 h and then decreased. There was a slight increase of insulin 1 h after the meal. 2H enrichment in the carbon 5 position of glucose (C5) increased after 2 h, whereas it decreased in plasma water. Consequently, fractional gluconeogenesis increased from 68.2 ± 7.2% before the meal to 75.5 ± 5.8% 8 h after the meal, the latter corresponding to 22 h without a glucose supply. These values are consistent with the exhaustion of glycogen stores after 24 h but represent the highest among values in the literature. The impact of methodological conditions is discussed.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-agroparistech.archives-ouvertes.fr/hal-02371420
Déposant : Claire Gaudichon <>
Soumis le : mardi 19 novembre 2019 - 21:48:34
Dernière modification le : mardi 26 mai 2020 - 03:13:09

Lien texte intégral

Identifiants

Collections

Citation

Claire Gaudichon, Hai-Yen Ta, Nadezda Khodorova, Marion Oberli, Isabelle Breton, et al.. Time course of fractional gluconeogenesis after meat ingestion in healthy adults: a D 2 O study. AJP - Endocrinology and Metabolism, American Physiological Society, 2018, 315 (4), pp.E454-E459. ⟨10.1152/ajpendo.00157.2018⟩. ⟨hal-02371420⟩

Partager

Métriques

Consultations de la notice

123