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Influence of the Soluble Insoluble Ratios of Cyclodextrins Polymers on the Viscoelastic Properties of Injectable Chitosan Based Hydrogels for Biomedical Application

Abstract : Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double–syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear–thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.
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Carla Palomino-Durand, Marco Lopez, Frederic Cazaux, Bernard Martel, Nicolas Blanchemain, et al.. Influence of the Soluble Insoluble Ratios of Cyclodextrins Polymers on the Viscoelastic Properties of Injectable Chitosan Based Hydrogels for Biomedical Application. Polymers, MDPI, 2019, 11 (2), pp.214. ⟨10.3390/polym11020214⟩. ⟨hal-02543185⟩

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