Integration of temporal and spatial patterning generates neural diversity - Archive ouverte HAL Access content directly
Journal Articles Nature Year : 2017

Integration of temporal and spatial patterning generates neural diversity

(1, 2) , (1) , (1) , (1) , (1) , (1) , (1) , (1) , (2) , (1) , (3) , (4) , (4) , (4) , (1, 3)
1
2
3
4

Abstract

In the Drosophila optic lobes, 800 retinotopically organized columns in the medulla act as functional units for processing visual information. The medulla contains over 80 types of neuron, which belong to two classes: uni-columnar neurons have a stoichiometry of one per column, while multi-columnar neurons contact multiple columns. Here we show that combinatorial inputs from temporal and spatial axes generate this neuronal diversity: all neuroblasts switch fates over time to produce different neurons; the neuroepithelium that generates neuroblasts is also subdivided into six compartments by the expression of specific factors. Uni-columnar neurons are produced in all spatial compartments independently of spatial input; they innervate the neuropil where they are generated. Multi-columnar neurons are generated in smaller numbers in restricted compartments and require spatial input; the majority of their cell bodies subsequently move to cover the entire medulla. The selective integration of spatial inputs by a fixed temporal neuroblast cascade thus acts as a powerful mechanism for generating neural diversity, regulating stoichiometry and the formation of retinotopy.
Fichier principal
Vignette du fichier
2017_Erclik_Nature_1.pdf (1.66 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02620278 , version 1 (25-05-2020)

Licence

Copyright

Identifiers

Cite

Ted Erclik, Xin Li, Maximilien Courgeon, Claire Bertet, Zhenqing Chen, et al.. Integration of temporal and spatial patterning generates neural diversity. Nature, 2017, 541 (7637), pp.365-370. ⟨10.1038/nature20794⟩. ⟨hal-02620278⟩

Collections

INRAE
19 View
28 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More