Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Food Chemistry Year : 2015

Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption

Abstract

The interactions occurring at the intestinal level between the fat-soluble vitamins A, D, E and K (FSVs) are poorly documented. We first determined each FSV absorption profile along the duodenal-colonic axis of mouse intestine to clarify their respective absorption sites. We then investigated the interactions between FSVs during their uptake by Caco-2 cells. Our data show that vitamin A was mostly absorbed in the mouse proximal intestine, while vitamin D was absorbed in the median intestine, and vitamin E and K in the distal intestine. Significant competitive interactions for uptake were then elucidated among vitamin D, E and K, supporting the hypothesis of common absorption pathways. Vitamin A also significantly decreased the uptake of the other FSVs but, conversely, its uptake was not impaired by vitamins D and K and even promoted by vitamin E. These results should be taken into account, especially for supplement formulation, to optimise FSV absorption.
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inserm-01478577 , version 1 (28-02-2017)

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Aurélie Goncalves, Stéphanie Roi, Marion Nowicki, Amélie Dhaussy, Alain Huertas, et al.. Fat-soluble vitamin intestinal absorption: Absorption sites in the intestine and interactions for absorption. Food Chemistry, 2015, 172, pp.155 - 160. ⟨10.1016/j.foodchem.2014.09.021⟩. ⟨inserm-01478577⟩
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