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Article dans une revue

A novel bioluminescence mouse model for monitoring oropharyngeal candidiasis in mice.

Abstract : Oropharyngeal Candida albicans (C. albicans) infection usually occurs in patients with altered cell-mediated immune response. Many animal models have been developed for studying the pathogenesis of disease. Here we describe a new model for real-time monitoring of oral candidiasis. Mice were rendered susceptible to oral candidiasis by injection with cortisone acetate. Oral infection was performed by placing a swab saturated with genetically engineered bioluminescent strain of C. albicans sublingually. An in vivo imaging technique, exploiting stably trasformed C. albicans that costitutively express luciferase, was adopted. This novel longitudinal study represents a powerful tool to: (1) test real-time progression of infection, (2) identify the target site of C. albicans in specific organs, (3) evaluate the efficacy of antifungal therapies and (4) explore the spread of C. albicans from the local to systemic compartment in a new way.
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Déposant : Christelle Lenormand <>
Soumis le : mardi 16 mai 2017 - 15:23:46
Dernière modification le : vendredi 29 mai 2020 - 07:17:45
Archivage à long terme le : : vendredi 18 août 2017 - 00:10:21


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Paolo Mosci, Eva Pericolini, Elena Gabrielli, Samyr Kenno, Stefano Perito, et al.. A novel bioluminescence mouse model for monitoring oropharyngeal candidiasis in mice.. Virulence, Landes Bioscience, 2013, 4 (3), pp.250-4. ⟨10.4161/viru.23529⟩. ⟨pasteur-01523596⟩



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