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Pré-Publication, Document De Travail Année : 2010

Likelihood Ratio Test process for Quantitative Trait Locus detection

Résumé

We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL on the interval [0, T] representing a chromosome (a QTL denotes a quantitative trait locus, i.e. a gene with quantitative effect on a trait). We give the asymptotic distribution of this LRT process under the null hypothesis that there is no QTL on [0, T] and under the alternative that there exists a QTL at t* on [0, T]. We show that the LRT is asymptotically the square of non linear interpolated process. We propose a simple and original method to calculate the maximum and the argmax of the LRT process using only statistics on markers and their ratio. We finally propose a new method to calculate thresholds for QTL detection.
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Dates et versions

hal-00483171 , version 1 (12-05-2010)
hal-00483171 , version 2 (10-01-2012)
hal-00483171 , version 3 (14-06-2012)
hal-00483171 , version 4 (17-12-2012)

Identifiants

  • HAL Id : hal-00483171 , version 2

Citer

Jean-Marc Azaïs, Céline Delmas, Charles-Elie Rabier. Likelihood Ratio Test process for Quantitative Trait Locus detection. 2010. ⟨hal-00483171v2⟩
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