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Intérêts des techniques de modifications ciblées du génome («Génome Editing») chez les animaux de rente

Abstract : Nowadays, new endonucleases make it possible to target precisely defined alterations in the genomic DNA of many species. With regard to livestock, the envisaged applications can be divided into three broad perspectives: (i) the projects with a basic research objective, when the mouse species cannot be used (horns development, seasonality, as examples) ; (ii) biomedical projects to create animal models of human pathologies when the mouse model is not adequate ; and (iii) agronomic projects aimed at providing an interesting character already described in another species or race, into a race or species not possessing such a character. These techniques represent a very effective alternative to introgression, while abolishing the species barrier. They may also be considered in support of genomic selection to eliminate adverse alleles once the use of these techniques of gene editing will be allowed in Europe, which is not yet the case.
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Jean-Luc Vilotte, Eric Pailhoux. Intérêts des techniques de modifications ciblées du génome («Génome Editing») chez les animaux de rente. Bulletin de l'Académie Vétérinaire de France, Académie vétérinaire de France, 2019, pp.1-6. ⟨10.4267/2042/70595⟩. ⟨hal-02620372⟩

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