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Le métabolisme des lipides dans l’ovaire : les modèles animaux au service de la gynécologie ?

Abstract : Female reproduction has energetic needs. When the energetic supply does not reach the energetic requirements (under-nutrition / intense physical activity), female fertility is altered. Studies have already highligthed the importance of energetic metabolism, especially carbohydrate metabolism, in the ovarian functionning in women. On the contrary, the importance of lipid metabolism is still poorly described. Data emerging from both lab and farm animal models enables to acquire knowledge on lipid metabolism impacts on ovarian follicular cells, on animal fertility and on embryo production. This review will endeavor to describe differences, in terms of lipid metabolism, existing between several ovarian cell types (germ / somatic), it will also address the effetcs, both favorable and unfavorable, of fatty acid supplementation and will define the protective role of cumulus cells towards the oocyte, regarding lipotoxicity.
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https://hal.inrae.fr/hal-02623078
Contributor : Migration Prodinra <>
Submitted on : Tuesday, May 26, 2020 - 7:10:17 AM
Last modification on : Thursday, August 5, 2021 - 3:49:42 AM

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Sébastien Elis, Philippe Monget, Svetlana Uzbekova. Le métabolisme des lipides dans l’ovaire : les modèles animaux au service de la gynécologie ?. Médecine de la Reproduction, 2019, 21 (2), pp.136-144. ⟨10.1684/mte.2019.0747⟩. ⟨hal-02623078⟩

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