Skip to Main content Skip to Navigation
Journal articles

Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon

Abstract : Background Parasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild population management. Here we studied genetic mechanisms driving parasite resistance in a large herbivore through a comprehensive approach combining measurements of neutral (16 microsatellites) and adaptive (MHC DRB1 exon 2) genetic diversity and two types of gastrointestinal parasites (nematodes and coccidia).ResultsWhile accounting for other extrinsic and intrinsic predictors known to impact parasite load, we show that both neutral genetic diversity and DRB1 are associated with resistance to gastrointestinal nematodes. Intermediate levels of multi-locus heterozygosity maximized nematodes resistance, suggesting that both in- and outbreeding depression might occur in the population. DRB1 heterozygosity and specific alleles effects were detected, suggesting the occurrence of heterozygote advantage, rare-allele effects and/or fluctuating selection. On the contrary, no association was detected between genetic diversity and resistance to coccidia, indicating that different parasite classes are impacted by different genetic drivers.ConclusionsThis study provides important insights for large herbivores and wild sheep pathogen management, and in particular suggests that factors likely to impact genetic diversity and allelic frequencies, including global changes, arealso expected to impact parasite resistance.
Document type :
Journal articles
Complete list of metadata

Cited literature [174 references]  Display  Hide  Download
Contributor : Migration ProdInra Connect in order to contact the contributor
Submitted on : Tuesday, May 26, 2020 - 3:28:59 PM
Last modification on : Saturday, September 24, 2022 - 2:36:04 PM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Elodie Portanier, Mathieu Garel, Sébastien Devillard, Daniel Maillard, Jocelyn Poissant, et al.. Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon. BMC Ecology, BioMed Central, 2019, 19, pp.1-14. ⟨10.1186/s12898-019-0228-x⟩. ⟨hal-02625811⟩



Record views


Files downloads