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Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing

Lin Zeng 1, 2, 3 Chen Ming 4, 5 Yan Li 1, 6, 7 Ling-Yan Su 1, 8 Yan-Hua Su 6, 9 Newton O. Otecko 1 Ambroise Dalecky 10, 11 Stephen Donnellan 12, 13 Ken Aplin 14, 15 Xiao-Hui Liu 16, 17 Ying Song 16, 17 Zhi-Bin Zhang 18 Ali Esmailizadeh 19 Saeed S. Sohrabi 19 Hojjat Asadollahpour Nanaei 19 He-Qun Liu 1, 2, 3 Ming-Shan Wang 1, 2, 3 Solimane Ag Atteynine 20, 21 Gérard Rocamora 22 Fabrice Brescia 23 Serge Morand 24 David M. Irwin 1, 25 Ming-Sheng Peng 1 Yong-Gang Yao 1, 8 Hai-Peng Li 4, 5 Dong-Dong Wu 1 Ya-Ping Zhang 1, 6, 26
Abstract : The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown rats migrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.
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https://hal.inrae.fr/hal-02627003
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Submitted on : Monday, June 14, 2021 - 3:48:25 PM
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Lin Zeng, Chen Ming, Yan Li, Ling-Yan Su, Yan-Hua Su, et al.. Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing. Molecular Biology and Evolution, Oxford University Press (OUP), 2018, 35 (1), pp.149-158. ⟨10.1093/molbev/msx276⟩. ⟨hal-02627003⟩

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