Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing
Lin Zeng
(1, 2, 3)
,
Chen Ming
(4, 5)
,
Yan Li
(1, 6, 7)
,
Ling-Yan Su
(1, 8)
,
Yan-Hua Su
(6, 9)
,
Newton O. Otecko
(1)
,
Ambroise Dalecky
(10, 11)
,
Stephen Donnellan
(12, 13)
,
Ken Aplin
(14, 15)
,
Xiao-Hui Liu
(16, 17)
,
Ying Song
(16, 17)
,
Zhi-Bin Zhang
(18)
,
Ali Esmailizadeh
(19)
,
Saeed S. Sohrabi
(19)
,
Hojjat Asadollahpour Nanaei
(19)
,
He-Qun Liu
(1, 2, 3)
,
Ming-Shan Wang
(1, 2, 3)
,
Solimane Ag Atteynine
(20, 21)
,
Gérard Rocamora
(22)
,
Fabrice Brescia
(23)
,
Serge Morand
(24)
,
David M. Irwin
(1, 25)
,
Ming-Sheng Peng
(1)
,
Yong-Gang Yao
(1, 8)
,
Hai-Peng Li
(4, 5)
,
Dong-Dong Wu
(1)
,
Ya-Ping Zhang
(1, 6, 26)
1
Kunming Institute of Zoology
2 State Key Laboratory of Genetic Resources and Evolution
3 Yunnan Laboratory of Molecular Biology of Domestic Animals
4 PICB - CAS-MPG Partner Institute for Computational Biology
5 Shanghai Institutes for Biological Sciences
6 Yunnan Agricultural University
7 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan
8 Key Laboratory of Animal Models and Human Disease Mechanisms
9 College of Animal Science and Technology
10 UMR CBGP - Centre de Biologie pour la Gestion des Populations
11 LPED - Laboratoire Population-Environnement-Développement
12 University of Adelaide
13 SAM - South Australian Museum
14 Smithsonian Institution
15 National Museum of Natural History
16 State Key Laboratory for Biology of Plant Diseases and Insect Pests
17 Institute of Plant Protection - IPP
18 Institute of Zoology, Chinese Academy of Sciences [Beijing]
19 Shahid Bahonar University of Kerman
20 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
21 USTTB - Université des Sciences, des Techniques et des Technologies de Bamako
22 Université des Seychelles
23 IAC - Institut Agronomique Néo-Calédonien
24 Centre d'Infectiologie Christophe Mérieux du Laos
25 LMP - Department of Laboratory Medicine and Pathobiology
26 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan
2 State Key Laboratory of Genetic Resources and Evolution
3 Yunnan Laboratory of Molecular Biology of Domestic Animals
4 PICB - CAS-MPG Partner Institute for Computational Biology
5 Shanghai Institutes for Biological Sciences
6 Yunnan Agricultural University
7 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan
8 Key Laboratory of Animal Models and Human Disease Mechanisms
9 College of Animal Science and Technology
10 UMR CBGP - Centre de Biologie pour la Gestion des Populations
11 LPED - Laboratoire Population-Environnement-Développement
12 University of Adelaide
13 SAM - South Australian Museum
14 Smithsonian Institution
15 National Museum of Natural History
16 State Key Laboratory for Biology of Plant Diseases and Insect Pests
17 Institute of Plant Protection - IPP
18 Institute of Zoology, Chinese Academy of Sciences [Beijing]
19 Shahid Bahonar University of Kerman
20 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
21 USTTB - Université des Sciences, des Techniques et des Technologies de Bamako
22 Université des Seychelles
23 IAC - Institut Agronomique Néo-Calédonien
24 Centre d'Infectiologie Christophe Mérieux du Laos
25 LMP - Department of Laboratory Medicine and Pathobiology
26 State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan
Yan Li
- Function : Author
- PersonId : 763439
- ORCID : 0000-0002-6336-0981
Yan-Hua Su
- Function : Author
Ambroise Dalecky
- Function : Author
- PersonId : 743974
- IdHAL : ambroise-dalecky
- ORCID : 0000-0002-5075-4121
- IdRef : 079329187
Serge Morand
- Function : Author
- PersonId : 757162
- ORCID : 0000-0003-3986-7659
- IdRef : 074297422
Abstract
The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown rats migrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.
Origin : Publisher files allowed on an open archive
