In silico and experimental data claiming safety aspects and beneficial attributes of the bacteriocinogenic strain enterococcus faecalis B3A-B3B - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Probiotics and Antimicrobial Proteins Year : 2018

In silico and experimental data claiming safety aspects and beneficial attributes of the bacteriocinogenic strain enterococcus faecalis B3A-B3B

Abstract

This study aimed at comparing the genome of Enterococcus faecalis B3A-B3B, a bacteriocinogenic strain recently isolated from a healthy Iraqi infant to those of Enterococci of clinical and beneficial grades. The putative genes gelE, cpd, efaAfm, ccf, agg, and cob coding for virulence factors were detected in B3A-B3B strain, which meanwhile resulted to be non-cytotoxic, non-hemolytic, devoid of inflammatory effects, and sensitive to most of the antibiotics tested except for clindamycin and trimethoprim, which resistance is usually ascribed to intrinsic nature. B3A-B3B strain was remarkable for its hydrophobicity, auto-aggregation, adhesion to human Caco-2 cells, and survival in simulated gastrointestinal conditions, and cholesterol assimilation fulfilling therefore key beneficial attributes.
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Dates and versions

hal-02627071 , version 1 (26-05-2020)

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Alaa Al Seraih, Yanath Belguesmia, Benoit Cudennec, John Baah, Djamel Drider. In silico and experimental data claiming safety aspects and beneficial attributes of the bacteriocinogenic strain enterococcus faecalis B3A-B3B. Probiotics and Antimicrobial Proteins, 2018, 10 (3), pp.456-465. ⟨10.1007/s12602-017-9357-8⟩. ⟨hal-02627071⟩
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