Neonatal consumption of oligosaccharides greatly increases l-cell density without significant consequence for adult eating behavior. - Archive ouverte HAL Access content directly
Journal Articles Nutrients Year : 2019

Neonatal consumption of oligosaccharides greatly increases l-cell density without significant consequence for adult eating behavior.

(1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2) , (1, 2) , (3) , (2, 4) , (1, 2)
1
2
3
4
Eric Chappuis
  • Function : Author

Abstract

Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or EEC density could be long-lasting and EEC-derived peptides do regulate short-term food intake, we hypothesized that neonatal OS consumption could modulate early EECs, with possible consequences for adult eating behavior. Suckling rats were supplemented with fructo-oligosaccharides (FOS), beta-galacto-oligosaccharides/inulin (GOS/In) mix, alpha-galacto-oligosaccharides (αGOS) at 3.2 g/kg, or a control solution (CTL) between postnatal day (PND) 5 and 14/15. Pups were either sacrificed at PND14/15 or weaned at PND21 onto standard chow. The effects on both microbiota and EEC were characterized at PND14/15, and eating behavior at adulthood. Very early OS supplementation drastically impacted the intestinal environment, endocrine lineage proliferation/differentiation particularly in the ileum, and the density of GLP-1 cells and production of satiety-related peptides (GLP-1 and PYY) in the neonatal period. However, it failed to induce any significant lasting changes on intestinal microbiota, enteropeptide secretion or eating behavior later in life. Overall, the results did not demonstrate any OS programming effect on satiety peptides secreted by L-cells or on food consumption, an observation which is a reassuring outlook from a human perspective.
Fichier principal
Vignette du fichier
2019_Le Dréan_Nutrients_1.pdf (4 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02627809 , version 1 (26-05-2020)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Gwenola Le Drean, Anne-Lise Pocheron, Hélène Billard, Isabelle I. Grit, Anthony Pagniez, et al.. Neonatal consumption of oligosaccharides greatly increases l-cell density without significant consequence for adult eating behavior.. Nutrients, 2019, 11 (9), pp.1-26. ⟨10.3390/nu11091967⟩. ⟨hal-02627809⟩
28 View
9 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More