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Article dans une revue

Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits

Charlotte Dupont 1, 2, 3 Delphine Ralliard-Rousseau 1 Anne Tarrade 1, 4 C. Faure 5, 3 Michele Dahirel 1, 4 B. Sion 6, 7 F. Brugnon 8, 9 R Levy 5, 3 Pascale Chavatte Palmer 1, 4
1 BDR - Biologie du développement et reproduction
2 Hôpital Jean Verdier [AP-HP]
3 Université Paris Nord (Paris 13)
4 Fondation PremUp
5 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
6 Pharmacologie fondamentale et clinique de la douleur
Neuro-Dol - Neuro-Dol, UdA - Université d'Auvergne - Clermont-Ferrand I, INSERM - Institut National de la Santé et de la Recherche Médicale : U766
7 Neuro-Dol - Neuro-Dol
8 CHU Clermont-Ferrand
9 Génétique, reproduction et développement
Abstract : The concept of Developmental Origins of Health and Disease initially stemmed from the developmental programming of metabolic diseases. Reproductive functions and fertility in adulthood may also be programmed during foetal development. We studied the impact of dietary-induced maternal hyperlipidaemia and hypercholesterolaemia (HH), administered at 10 weeks of age and throughout the gestation and lactation, on male reproductive functions of rabbit offspring. Male rabbits born to HH dams and fed a control diet had significantly lighter testes and epididymes compared with rabbits born to control dams at adulthood. No significant changes in sperm concentration, sperm DNA integrity and sperm membrane composition were observed, but serum-free testosterone concentrations were decreased in HH males. This study confirms the importance of maternal metabolic status for the development of male reproductive organs.
Keywords : dohad; foetal programming; male reproductive function; maternal diet; maternal hyperlipidaemia and hypercholesterolaemia; rabbit
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Article dans une revue
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https://hal.inrae.fr/hal-02630542
Déposant : Migration Prodinra <>
Soumis le : mercredi 27 mai 2020 - 05:55:28
Dernière modification le : mercredi 19 août 2020 - 11:18:38

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Charlotte Dupont, Delphine Ralliard-Rousseau, Anne Tarrade, C. Faure, Michele Dahirel, et al.. Impact of maternal hyperlipidic hypercholesterolaemic diet on male reproductive organs and testosterone concentration in rabbits. Journal of Developmental Origins of Health and Disease, Cambridge University Press, 2014, 5 (3), pp.183-188. ⟨10.1017/S204017/4414000087⟩. ⟨hal-02630542⟩

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