Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Gastroenterology research and practice Year : 2015

Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models

Abstract

Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments. Probiotic microorganisms appear as an alternative for these patients; however, probiotic characteristics are strain dependent and each probiotic needs to be tested to understand the underlining mechanisms involved in their beneficial properties. Genetic modification of lactic acid bacteria (LAB) was also described as a tool for new IBD treatments. The first part of this review shows different genetically modified L(GM-LAB) described for IBD treatment since 2000. Then, the two principally studied strategies are discussed (i) GM-Lproducing antioxidant enzymes and (ii) GM-Lproducing the anti-inflammatory cytokine IL-10. Different delivery systems, including protein delivery and DNA delivery, will also be discussed. Studies show the efficacy of GM-L(using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative. These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.
Fichier principal
Vignette du fichier
2015_LeBlanc_Gastroenterology Research and Practice_1.pdf (1.24 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02637902 , version 1 (28-05-2020)

Licence

Attribution

Identifiers

Cite

Alejandra de Moreno de Leblanc, Silvina del Carmen, Jean-Marc J.-M. Chatel, Anderson Miyoshi, Vasco Azevedo, et al.. Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models. Gastroenterology research and practice, 2015, pp.1-8. ⟨10.1155/2015/146972⟩. ⟨hal-02637902⟩
35 View
26 Download

Altmetric

Share

Gmail Facebook X LinkedIn More