Human hydroxytyrosol's absorption and excretion from a nutraceutical - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Journal of Functional Foods Year : 2016

Human hydroxytyrosol's absorption and excretion from a nutraceutical


Among the various (poly)phenols that are being sold as such or as part of a more complex mixture, hydroxytyrosol (HT) is the only one that bears a European Food Safety Authority health claim. Therefore, several HT-based products are being developed and sold and it becomes necessary to evaluate its accessibility following ingestion. Twenty-one volunteers were recruited for a randomized, crossover, placebo-controlled, and double-blind intervention study.We performed a Latin square design: after one-week washout, i.e. olive-free diet, subjects were randomly assigned to the placebo (maltodextrin), 5, or 25 mg/day HT group. Twenty-four hour urine samples were collected after the intervention week, and baseline urines were collected the week before the study and during periods of washout. The results show that HT given as the foremost component of a nutraceutical preparation is bioavailable and is recovered in the urine chiefly as sulphate-3′.
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hal-02639403 , version 1 (28-05-2020)



Olha Khymenets, M. Carmen Crespo, Olivier O. Dangles, Njara Rakotomanomana, Cristina Andres-Lacueva, et al.. Human hydroxytyrosol's absorption and excretion from a nutraceutical. Journal of Functional Foods, 2016, 23, pp.278-282. ⟨10.1016/j.jff.2016.02.046⟩. ⟨hal-02639403⟩
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