An insoluble polymeric network containing cyclodextrins (CDs) and amino, hydroxyl and carboxylic groups, was used for the detoxification of multicontaminated wastewaters. The comparison of its sorption capacity with that of a similarly prepared starch material showed superior efficiency towards organic compounds, though maintaining the same efficiency towards inorganic species. The incorporation of cyclodextrin cavity into a solid network provides an easy separation of pollutants from water, after their uptake onto the sorbent surface. In fact, the presence of CDs ensures the formation of inclusion complexes enhancing the sorption properties. The proposed sorbent also shows good sorption capacity for cations and other inorganic compounds, which is mandatory for the treatment of multicontaminated wastewaters.