Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network
M. Shahid Mukhtar
(1)
,
Anne-Ruxandra Carvunis
(2, 3, 4)
,
Matija Dreze
(2, 3, 5)
,
Petra Epple
(1)
,
Jens Steinbrenner
(6)
,
Jonathan Moore
(7)
,
Murat Taşan
(8)
,
Mary Galli
(9)
,
Tong Hao
(2)
,
Marc T. Nishimura
(1)
,
Samuel J. Pevzner
(2, 3, 10)
,
Susan E. Donovan
(6)
,
Lila Ghamsari
(2, 3)
,
Balaji Santhanam
(2, 3)
,
Viviana Romero
(2)
,
Matthew M. Poulin
(2, 3)
,
Fana Gebreab
(2)
,
Bryan J. Gutierrez
(2)
,
Stanley Tam
(2, 3)
,
Dario Monachello
(11)
,
Mike Boxem
(12)
,
Christopher J. Harbort
(1)
,
Nathan Mcdonald
(1)
,
Lantian Gai
(9)
,
Huaming Chen
(9)
,
Yijian He
(1)
,
Jean Vandenhaute
(5)
,
Frederick P. Roth
(2, 8)
,
David E. Hill
(2, 3)
,
Joseph R. Ecker
(9, 13)
,
Marc Vidal
(2, 3)
,
Jim Beynon
(6, 7)
,
Pascal Braun
(2, 3)
,
Jeffery L. Dangl
(1, 14)
1
Department of Biology
2 HMS - Harvard Medical School [Boston]
3 Department of Genetics [Boston]
4 Faculté de Médecine
5 Faculté Universitaire Notre Dame de la Paix
6 School of Life Sciences
7 University of Warwick [Coventry]
8 department of biological chemistry and molecular pharmacology
9 Salk Institute for Biological Studies
10 BU - Boston University [Boston]
11 URGV - Unité de recherche en génomique végétale
12 Universiteit Utrecht / Utrecht University [Utrecht]
13 The Salk Institute for Biological Studies
14 University of North Carolina
2 HMS - Harvard Medical School [Boston]
3 Department of Genetics [Boston]
4 Faculté de Médecine
5 Faculté Universitaire Notre Dame de la Paix
6 School of Life Sciences
7 University of Warwick [Coventry]
8 department of biological chemistry and molecular pharmacology
9 Salk Institute for Biological Studies
10 BU - Boston University [Boston]
11 URGV - Unité de recherche en génomique végétale
12 Universiteit Utrecht / Utrecht University [Utrecht]
13 The Salk Institute for Biological Studies
14 University of North Carolina
Tong Hao
- Fonction : Auteur
- PersonId : 797996
- ORCID : 0000-0001-7908-3256
Dario Monachello
- Fonction : Auteur
- PersonId : 1204840
- IdHAL : dario-monachello
- ORCID : 0000-0001-7551-0214
Marc Vidal
- Fonction : Auteur
- PersonId : 756524
- ORCID : 0000-0003-3391-5410
Pascal Braun
- Fonction : Auteur
- PersonId : 1306970
Résumé
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and similar to 8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.