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Sex determination: switch and suppress

Abstract : The transcription factor Dmrt1 regulates male sexual development from flies and worms to humans. A newly discovered function is to suppress female differentiation in the testes. Thus, the gonadal fate decision is not final but has to be actively maintained throughout life.
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Submitted on : Friday, May 29, 2020 - 7:31:00 AM
Last modification on : Thursday, December 10, 2020 - 6:16:04 PM

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Amaury Herpin, Manfred Schartl. Sex determination: switch and suppress. Current Biology - CB, Elsevier, 2011, 21 (17), pp.R656-R659. ⟨10.1016/j.cub.2011.07.026⟩. ⟨hal-02647597⟩

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