Skip to Main content Skip to Navigation
New interface
Journal articles

Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Abstract : Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.
Document type :
Journal articles
Complete list of metadata

https://hal.inrae.fr/hal-02647780
Contributor : Migration ProdInra Connect in order to contact the contributor
Submitted on : Friday, May 29, 2020 - 8:01:55 AM
Last modification on : Tuesday, September 27, 2022 - 4:40:41 AM

Identifiers

Citation

Sinem Tuncel, Aurélien Trivella, Devrim Atilla, Khalil Bennis, Huguette Savoie, et al.. Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties. Molecular Pharmaceutics, 2013, 10 (10), pp.3706 - 3716. ⟨10.1021/mp400207v⟩. ⟨hal-02647780⟩

Share

Metrics

Record views

99