Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Sinem Tuncel; Aurélien Trivella; Devrim Atilla; Khalil Bennis; Huguette Savoie; Florian Albrieux; Laetitia Delort; Hermine Billard; Virginie Dubois; Vefa Ahsen; Florence Caldefie-Chezet; Claire Richard; Ross W. Boyle; Sylvie Ducki; Fabienne Dumoulin

doi:10.1021/mp400207v

Article dans une revue

Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Sinem Tuncel ¹ Aurélien Trivella ² Devrim Atilla ¹ Khalil Bennis ² Huguette Savoie ³ Florian Albrieux ⁴ Laetitia Delort ⁵ Hermine Billard ⁵ Virginie Dubois ⁵ Vefa Ahsen ¹ Florence Caldefie-Chezet ⁵ Claire Richard ² Ross W. Boyle ³ Sylvie Ducki ^{6, 2, *} Fabienne Dumoulin ^{1, *}

* Auteur correspondant

1 Gebze Institute of Technology

2 ICCF - Institut de Chimie de Clermont-Ferrand - Clermont Auvergne

3 Department of Chemistry

4 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

5 UNH - Unité de Nutrition Humaine

6 UdA - Université d'Auvergne - Clermont-Ferrand I

Abstract : Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.

Mots-clés : antivascular tumor vasculature cell

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Article dans une revue

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Sciences du Vivant [q-bio]

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Soumis le : vendredi 29 mai 2020 - 08:01:55
Dernière modification le : jeudi 10 décembre 2020 - 15:22:04

Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

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