Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Sinem Tuncel; Aurélien Trivella; Devrim Atilla; Khalil Bennis; Huguette Savoie; Florian Albrieux; Laetitia L. Delort; Hermine H. Billard; Virginie Dubois; Vefa Ahsen; Florence F. Caldefie-Chezet; Claire Richard; Ross W. Boyle; Sylvie Ducki; Fabienne Dumoulin

doi:10.1021/mp400207v

Journal articles

Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Sinem Tuncel ¹ Aurélien Trivella ^{2, 2} Devrim Atilla ¹ Khalil Bennis ² Huguette Savoie ³ Florian Albrieux ⁴ Laetitia L. Delort ⁵ Hermine H. Billard ⁵ Virginie Dubois ⁵ Vefa Ahsen ¹ Florence F. Caldefie-Chezet ⁵ Claire Richard ^{2, 2} Ross W. Boyle ³ Sylvie Ducki ^{6, 2, *} Fabienne Dumoulin ^{1, *}

* Corresponding author

1 Gebze Institute of Technology

2 ICCF - Institut de Chimie de Clermont-Ferrand

3 Department of Chemistry

4 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

5 UNH - Unité de Nutrition Humaine

6 UdA - Université d'Auvergne - Clermont-Ferrand I

Abstract : Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.

Keywords : phthalocyanine chalcone photodynamic therapy dual effect substituted zinc phthalocyanine vascular disrupting agent oxygen quantum yield singlet oxygen photosensitizer 1.3 diphenylisobenzofuran therapy growth

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadata

https://hal.inrae.fr/hal-02647780
Contributor : Migration ProdInra Connect in order to contact the contributor
Submitted on : Friday, May 29, 2020 - 8:01:55 AM
Last modification on : Tuesday, September 27, 2022 - 4:40:41 AM

Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Identifiers

Collections

Citation

Export

Metrics

99

Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Identifiers

Collections

Citation

Export

Share

Metrics

99