The precise arrangement of plant organs, also called phyllotaxis, has fascinated scientists from multiple disciplines. Whereas early work focused on morphological observations of phyllotaxis, recent findings have started to reveal the mechanisms behind this process, showing how molecular regulation and biochemical gradients interact with physical components to generate such precise patterns of growth. Here, I review new insights into the regulation of phyllotactic patterning and provide an overview of the various factors that can drive these robust growth patterns.