Skip to Main content Skip to Navigation
Journal articles

Survival of exfoliated epithelial cells: a delicate balance between anoikis and apoptosis

Abstract : The recovery of exfoliated cells from biological fluids is a noninvasive technology which is in high demand in the field of translational research. Exfoliated epithelial cells can be isolated from several body fluids (i.e., breast milk, urines, and digestives fluids) as a cellular mixture (senescent, apoptotic, proliferative, or quiescent cells). The most intriguing are quiescent cells which can be used to derive primary cultures indicating that some phenotypes retain clonogenic potentials. Such exfoliated cells are believed to enter rapidly in anoikis after exfoliation. Anoikis can be considered as an autophagic state promoting epithelial cell survival after a timely loss of contact with extracellular matrix and cell neighbors. This paper presents current understanding of exfoliation along with the influence of methodology on the type of gastrointestinal epithelial cells isolated and, finally, speculates on the balance between anoikis and apoptosis to explain the survival of gastrointestinal epithelial cells in the environment.
Document type :
Journal articles
Complete list of metadata

Cited literature [82 references]  Display  Hide  Download

https://hal.inrae.fr/hal-02649948
Contributor : Migration Prodinra <>
Submitted on : Friday, May 29, 2020 - 12:47:57 PM
Last modification on : Wednesday, October 14, 2020 - 4:15:29 AM

File

2011_Kaeffer_Journal of Biomed...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Bertrand Kaeffer. Survival of exfoliated epithelial cells: a delicate balance between anoikis and apoptosis. Journal of Biomedicine and Biotechnology, Hindawi Publishing Corporation, 2011, pp.534139. ⟨10.1155/2011/534139⟩. ⟨hal-02649948⟩

Share

Metrics

Record views

27

Files downloads

70