HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

A retrosynthetic biology approach to therapeutics: from conception to delivery

Abstract : De novo biosynthetic pathways are designed, assembled and optimized to produce high-value compounds such as drugs and chemical building blocks from renewable resources. Microorganisms are used as synthetic platforms of systems biology where biochemical pathways are engineered into the host metabolic network. Retrosynthetic biology offers a creative pathway design concept that has gained interest because of its potential to identify novel metabolic ways for therapeutic production. Retrosynthetic biology uses the backward search of retrosynthetic analysis to devise and optimize tailor-made pathways. The retrosynthetic process can be seamlessly integrated into a complete circuitry system for therapeutic applications where production, sensing and delivery act as constitutive interconnecting parts. The aim of this review is to highlight recent efforts toward synthetic design for therapeutic development.
Document type :
Journal articles
Complete list of metadata

Contributor : Migration Prodinra Connect in order to contact the contributor
Submitted on : Friday, May 29, 2020 - 5:48:19 PM
Last modification on : Wednesday, August 19, 2020 - 1:28:02 PM




Anne-Gaëlle Planson, Pablo Carbonell, Ioana Grigoras, Jean-Loup Faulon. A retrosynthetic biology approach to therapeutics: from conception to delivery. Current Opinion in Biotechnology, Elsevier, 2012, 23 (6), pp.948-956. ⟨10.1016/j.copbio.2012.03.009⟩. ⟨hal-02651873⟩



Record views