The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles American Journal of Physiology - Cell Physiology Year : 2012

The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis

Abstract

The AMPactivated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a sensor of cellular energy status switch regulating several systems including glucose and lipid metabolism. Recently, AMPK has been implicated in the control of skeletal muscle mass by decreasing mTORC1 activity and increasing protein degradation through regulation of ubiquitin-proteasome and autophagy pathways. In this review, we give an overview of the central role of AMPK in the control of skeletal muscle plasticity. We detail particularly its implication in the control of the hypertrophic and atrophic signaling pathways. In the light of these cumulative and attractive results, AMPK appears as a key player in regulating muscle homeostasis and the modulation of its activity may constitute a therapeutic potential in treating muscle wasting syndromes in humans.
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hal-02652061 , version 1 (29-05-2020)

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Anthony M.J. Sanchez, Robin Candau, Alfredo Csibi, Allan F. Pagano, Audrey Raibon, et al.. The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis. American Journal of Physiology - Cell Physiology, 2012, 303 (5), pp.C475-C485. ⟨10.1152/ajpcell.00125.2012⟩. ⟨hal-02652061⟩
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