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Journal Articles (Review Article) Current Genomics Year : 2007

Myostatin in the pathophysiology of skeletal muscle


Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Here we discuss the recent developments and the controversies in myostatin research, focusing on the molecular and cellular mechanisms underlying the actions of myostatin on skeletal muscle and the potential therapeutic role of myostatin on muscle-related disorders.
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hal-02654025 , version 1 (29-05-2020)


  • HAL Id : hal-02654025 , version 1
  • PRODINRA : 26510


Gilles Carnac, Barbara Vernus, Anne Bonnieu. Myostatin in the pathophysiology of skeletal muscle. Current Genomics, 2007, 8 (7), pp.415-422. ⟨hal-02654025⟩
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